IP International Journal of Orthopaedic Rheumatology
Official Publication of Indian Orthopaedic Rheumatology Association
Official Publication of Indian Orthopaedic Rheumatology Association
Print ISSN:-2581-8112
Online ISSN:-2581-9151
CODEN : IIJOAT
Original Article
Author Details :
Volume : 10, Issue : 2, Year : 2024
Article Page : 83-89
https://doi.org/10.18231/j.ijor.2024.016
Abstract
Introduction: Osteoporosis, a prevalent bone disorder characterized by reduced bone mineral density and structural deterioration, often involves mineral and vitamin D imbalances.
Aim & Objective: This observational study examines the correlation between serum calcium, phosphorus, and vitamin D levels in osteoporotic patients to understand the interplay of these biomarkers in bone health.
This observational study was done on 100 osteoporotic patients diagnosed with DEXA and BMD scans (females less than 50 years and males more than 60 years). The estimation of calcium, phosphorus and vitamin D were done on vitros 5600 where calcium and phosphorus calculation based on the principle of spectrophotometry and vitamin D on the principle of radio immunoassay.
Results: The average values of calcium, phosphorus and vitamin D we got were 6.66mg/dl, 2.94mg/dl and 24.96ng/ml respectively. Data analysis reveals that individuals with vitamin D deficiency or insufficiency predominantly exhibit hypocalcemia, with 55.21% and 22% showing low calcium levels, respectively. Only a small subset with sufficient vitamin D shows normal calcium levels, suggesting a positive relationship between vitamin D status and calcium regulation. This trend is further illustrated in the scatter plot where higher vitamin D levels correlate with increased calcium values, albeit with some data variability. In addition, a strong association between calcium and phosphorus levels was observed: 96% of hypocalcemic individuals had normal phosphorus, while 4% with normal calcium displayed corresponding normal phosphorus levels. Conversely, the relationship between vitamin D and phosphorus was minimal, as evidenced by the Pearson correlation coefficient (???? = 0.01609), indicating a weak inverse association. This is visually supported in the scatter plot, where phosphorus levels remain relatively stable across varied vitamin D concentrations.
Conclusion: These findings suggest that while vitamin D strongly influences calcium homeostasis, it has minimal impact on phosphorus regulation. The study underscores the importance of monitoring vitamin D and calcium levels in osteoporosis, while phosphorus appears relatively unaffected by vitamin D status. Further research is needed to clarify these associations and their clinical implications.
Keywords: Osteoporosis, Serum Calcium, Phosphorus, and Vitamin D
How to cite : Medhi S, Das C, Lahon D, Bora M, Deb R, Correlation of serum calcium, phosphorus, and Vitamin D in osteoporosis: An observational study. IP Int J Orthop Rheumatol 2024;10(2):83-89
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