- Visibility 58 Views
- Downloads 35 Downloads
Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study
- Author Details:
-
Kolla Saketh
-
Y. Thimma Reddy
-
J. Satyanarayana
-
Gattu Naresh
Background: Rheumatoid arthritis(RA) is a systemic auto-immune disorder, involving inflammation of the joints. Non-Steroidal Anti-inflammatory drugs (NSAIDs) are used to reduce the symptoms RA but the Non- Selective NSAIDs such as diclofenac is associated with significant gastro-intestinal side effects including bleeding, ulceration and perforations. NSAIDs like celecoxib which is selective cyclooxygenase (COX) II inhibitor is used widely in order to reduce the GI toxicity.
Objectives: To compare the efficacy of celecoxib and diclofenac in the pain management of RA.
Methods: 30 RA patients were included in the study. Group A (15 patients) was given celecoxib 100mg twice daily (200mg/day) and Group B(15 patients) was given diclofenac 50mg thrice daily(150mg/day) for 6 weeks. Pain was assessed before the start of medication and at the end of 6 weeks using Visual analogue score (VAS).
Results: Mean age, mean pre-medication VAS scores in both groups was similar. VAS scores were decreased in both groups at the end of 6 weeks, however VAS scale was more less in Group A when compared with Group B.
Interpretation and conclusions: Celecoxib is more effective when compared with diclofenac in pain management of Rheumatoid arthritis.
Key Words: Rheumatoid Arthritis, Selective COX II inhibitors, NSAIDs, Pain
References
- Wolfe M, Lichtenstein D, Singh G. Medical progress: gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. NEJM 1999;340(24):1888–1899.
- Deeks JJ, Smith LA, Bradley MD. Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: Systematic review of randomised controlled trials. BMJ. 2002;325(7365):619–623.
- 3.Leese PT, Hubbard RC, Karim A, et al. Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults : a randomized, controlled trial, J Clin Pharmacol 2000;40:124.
- Gimbel JS, Bruggger A, Zhao W et al. Efficacy and tolerability of celecoxib versus hydrocodone in the treatment of pain after ambulatory orthopaedic surgery in adults. Clin Ther 2001;23:228.
- Sriwatanakul K, Kelvie W, Lasagna L, et al. Studies with different types of visual analog scales for measurement of pain. Clin Pharmacol Ther 1983;34:234.
- Emery P, Zeidler H, Kvien TK, Guslandi M, Naudin R, Stead H, et al. Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double- blind comparison. Lancet. 1999;354(9196):2106–2111.
- Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, et al. Gastrointestinal toxicity with celecoxib vs non-steroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA. 2000;284(10):1247–1255.
- Simon LS, Weaver AL, Graham DY, Kivitz AJ, Lipsky PE, Hubbard RC, et al. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. JAMA. 1999;282(20):1921–1928.
- Chen Y-F, Jobanputra P, Barton P, Bryan S, Fry-Smith A, Harris G, et al. Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: A systematic review and economic evaluation. Health Technol Assess (Rockv) 2008;12(11):iii–158.
How to Cite This Article
Vancouver
Saketh K, Reddy YT, Satyanarayana J, Naresh G. Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study [Internet]. IP Int J Orthop Rheumatol. 2016 [cited 2025 Oct 07];2(1):13-14. Available from: https://doi.org/
APA
Saketh, K., Reddy, Y. T., Satyanarayana, J., Naresh, G. (2016). Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study. IP Int J Orthop Rheumatol, 2(1), 13-14. https://doi.org/
MLA
Saketh, Kolla, Reddy, Y. Thimma, Satyanarayana, J., Naresh, Gattu. "Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study." IP Int J Orthop Rheumatol, vol. 2, no. 1, 2016, pp. 13-14. https://doi.org/
Chicago
Saketh, K., Reddy, Y. T., Satyanarayana, J., Naresh, G.. "Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study." IP Int J Orthop Rheumatol 2, no. 1 (2016): 13-14. https://doi.org/