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Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study
- Author Details:
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Kolla Saketh
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Y. Thimma Reddy
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J. Satyanarayana
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Gattu Naresh
Background: Rheumatoid arthritis(RA) is a systemic auto-immune disorder, involving inflammation of the joints. Non-Steroidal Anti-inflammatory drugs (NSAIDs) are used to reduce the symptoms RA but the Non- Selective NSAIDs such as diclofenac is associated with significant gastro-intestinal side effects including bleeding, ulceration and perforations. NSAIDs like celecoxib which is selective cyclooxygenase (COX) II inhibitor is used widely in order to reduce the GI toxicity.
Objectives: To compare the efficacy of celecoxib and diclofenac in the pain management of RA.
Methods: 30 RA patients were included in the study. Group A (15 patients) was given celecoxib 100mg twice daily (200mg/day) and Group B(15 patients) was given diclofenac 50mg thrice daily(150mg/day) for 6 weeks. Pain was assessed before the start of medication and at the end of 6 weeks using Visual analogue score (VAS).
Results: Mean age, mean pre-medication VAS scores in both groups was similar. VAS scores were decreased in both groups at the end of 6 weeks, however VAS scale was more less in Group A when compared with Group B.
Interpretation and conclusions: Celecoxib is more effective when compared with diclofenac in pain management of Rheumatoid arthritis.
Key Words: Rheumatoid Arthritis, Selective COX II inhibitors, NSAIDs, Pain
References
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How to Cite This Article
Vancouver
Saketh K, Reddy YT, Satyanarayana J, Naresh G. Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study [Internet]. IP Int J Orthop Rheumatol. 2016 [cited 2025 Oct 07];2(1):13-14. Available from: https://doi.org/
APA
Saketh, K., Reddy, Y. T., Satyanarayana, J., Naresh, G. (2016). Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study. IP Int J Orthop Rheumatol, 2(1), 13-14. https://doi.org/
MLA
Saketh, Kolla, Reddy, Y. Thimma, Satyanarayana, J., Naresh, Gattu. "Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study." IP Int J Orthop Rheumatol, vol. 2, no. 1, 2016, pp. 13-14. https://doi.org/
Chicago
Saketh, K., Reddy, Y. T., Satyanarayana, J., Naresh, G.. "Efficacy of celecoxib and diclofenac in the pain management of Rheumatoid Arthritis: A Clinical study." IP Int J Orthop Rheumatol 2, no. 1 (2016): 13-14. https://doi.org/